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Breakdown of B cell tolerance in Fkbp11high mice. (A to E) Anti-dsDNA IgG (A), anti-dsDNA IgM (B), RF IgM (C), anti-thyroglobulin IgM (D), and anti-actin IgM (E) titers were determined by ELISA in sera of 8-month-old Fkbp11high and littermate control mice, by ELISA. Each point represents the result for one animal. (***P < 0.005, Mann & Whitney test). The dotted lines indicate the means for control groups.
