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. 2015 Jun 18;3(3):265–279. doi: 10.1002/iid3.65

Figure 5.

Figure 5

Fkbp11 overexpression increases lymphoproliferation and hypergammaglobulinemia in lpr/lpr Fkbp11high mice. (A, B) Sera from 9-month-old lpr/lpr Fkbp11high and B6lpr/lpr littermate control mice were collected then titers of anti-dsDNA IgM (A) and IgG (B) were determined by ELISA. Each point represents the result for one animal. (C to E) Quantification of total number of splenic cells (C), DN (B220+CD3+CD4-CD8-) splenic cells (D), and of the proportion of DN lymph node cells (E) from 9-month-old B6lpr/lpr and lpr/lpr Fkbp11high mice (A, B: n = 15 mice in each group; C: n = 9 mice in each group). (F, G) Sera from 9-month-old lpr/lpr Fkbp11high and B6lpr/lpr mice were collected then total IgM (F) and IgG (G) titers were determined by ELISA. Each point represents the result for one animal. (*P < 0.05, **P < 0.01, Mann & Whitney test). (Error bars, SEM). The dotted lines indicate the means for control groups.