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Microbiota can be controlled by many factors including diet, physical activity, genetics, and epigenetics. The influence of gut microbiota on the host may be partially explained by the generation of short chain fatty acids, including the beneficial acetate, butyrate and propionate, and non-beneficial lactate. These short chain fatty acids acting on cell surface receptors, including GPR43, GPR41, and Olfr78 regulate blood pressure. GPR41 and Olfr78 counter-regulate each other.
