Table 4.
Association of PZA resistance with M. tuberculosis lineage in multivariable regression analysis (N=27,428)
| Characteristic | Adjusted prevalence ratio (95% CI) |
||
|---|---|---|---|
| Non MDR TB cases N=26,982 |
MDR TB cases N=446 |
||
| Phylogenetic lineage | EuroAmerican | 1.24 (0.80-1.92) | 0.83 (0.61-1.13) |
| IndoOceanic | 2.26 (1.53-3.36) | 0.54 (0.32-0.90) | |
| East African Indian | 1.17 (0.63-2.19) | 0.82 (0.49-1.40) | |
| East Asian | 1.00 | 1.00 | |
|
| |||
| Age group | 0-24 | 0.90 (0.63-1.30) | 1.12 (0.83-1.52) |
| 25-44 | 0.72 (0.57-0.93) | 0.85 (0.64-1.13) | |
| 45+ | 1.00 | 1.00 | |
|
| |||
| Race/ethnicity | Hispanic | 0.85 (0.52-1.38) | 1.14 (0.75-1.72) |
| Asian | 1.48 (0.89-2.46) | 0.93 (0.63-1.39) | |
| Black | 1.03 (0.67-1.59) | 0.87 (0.55-1.40) | |
| White/Other | 1.00 | 1.00 | |
|
| |||
| Foreign-born | Yes | 1.20 (0.84-1.71) | 0.71 (0.53-0.97) |
| No | 1.00 | 1.00 | |
|
| |||
| Previous TB diagnosis | Yes | 1.40 (0.87-2.26) | 1.14 (0.86-1.52) |
| No | 1.00 | 1.00 | |
|
| |||
| Site of TB disease | EPTB | 1.09 (0.82-1.46) | 1.06 (0.71-1.58) |
| EPTB&PTB | 1.05 (0.72-1.54) | 0.60 (0.34-1.06) | |
| PTB | 1.00 | ||
|
| |||
| HIV infection | Yes | 0.80 (0.43-1.46) | 1.00 (0.65-1.52) |
| No/unknown | 1.00 | 1.00 | |