Is the case definition adequate? (Yes, with independent validation) |
+ |
+ |
+ |
+ |
+ |
Representatives of cases? (Consecutive or obviously representative series of cases) |
+ |
− |
+ |
− |
+ |
Selection of controls? (Community controls) |
+ |
+ |
+ |
− |
+ |
Definition of controls? (No history of studied end point) |
+ |
+ |
+ |
+ |
+ |
Study controls for age/sex? (Matching or multivariable analysis) |
+ |
− |
+ |
− |
+ |
Study controls for at least three additional factors? |
− |
− |
− |
− |
− |
Ascertainment of exposure? (Secure record, structured interview by health-care practitioner, blind to case/control status) |
+ |
+ |
+ |
+ |
+ |
Same method of ascertainment of cases/controls? (Yes) |
− |
+ |
+ |
+ |
+ |
Nonresponse rate? (Same for both groups) |
− |
+ |
+ |
+ |
+ |
Total overall score (Maximum = 9) |
6 |
6 |
8 |
5 |
8 |