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. Author manuscript; available in PMC: 2015 Sep 22.
Published in final edited form as: Andrology (Los Angel). 2015 May 25;4(1):132. doi: 10.4172/2167-0250.1000132

Figure 1. Prevention of CVOD in middle aged Fischer 344 rat by oral treatment with tadalafil (TAD), COMP4 and combination of COMP4 + TAD, as determined by dynamic infusion cavernosometry.

Figure 1

5MO: Five month-old animals at the time cavernosometry and euthanasia; 12 MO : Middle aged control, 12 month-old at the time of cavernosometry and euthanasia. COMP4: 10 mo old animals treated with composition 4 for two months and sacrificed at 12 months; -TAD: 10 month old animals treated with tadalafil for 2 months and sacrificed at 12 mo; COMP4+TAD: 10 mo old animals animals treated with a combination of composition 4 and tadalafil for 2 months and sacrificed at 12 months of age. **p<0.01; * p<0.05 respect to 12 MO. ### p<0.005 respect to 5-MO. (n=6)