Table 1.
Baseline characteristics
| Characteristics | Normal (n = 39) |
MCI/AD (n = 18) |
P value |
|---|---|---|---|
| Mean (SD) | Mean (SD) | ||
| Demographics | |||
| Age (y) | 68.2 (6.98) | 70.6 (7.31) | .25 |
| Sex (m, %) | 51.3 | 44.4 | .64 |
| Education (y) | 15.62 (2.37) | 15.28 (3.48) | .71 |
| MMSE | 29.3 (1.41) | 27.7 (2.27) | .01 |
| BMI | 28.23 (4.67) | 26.94 (4.07) | .28 |
| Laboratory values | |||
| Fasting glucose, mg/dL | 94.18 (15.48) | 91.22 (13.31) | .49 |
| Amyloid-β (40), pg/mL | 192.37 (73.79) | 180.11 (75.10) | .57 |
| Amyloid-β (42), pg/mL | 24.73 (23.77) | 17.85 (8.02) | .11 |
| Amyloid-β 42/40 ratio | 0.18 (0.39) | 0.11 (0.04) | .27 |
| Δ Amyloid-β (40), pg/mL | 41.34 (57.16) | −3.14 (40.93) | .002 |
| Δ Amyloid-β (42), pg/mL | 5.64 (10.65) | −0.15 (3.77) | .004 |
Abbreviations: MCI, mild cognitive impairment; AD, Alzheimer's disease; SD, standard deviation; MMSE, mini-mental state examination; BMI, body mass index.
NOTE. Aβ40 and 42 (Δ) values were calculated as the difference between the value at 10 minutes and the maximum value occurring before 10 minutes (at either 0 or 5 minutes).