Table 11.
Sidechain-sidechain connected antimicrobial peptides: further classification of single-chain peptides containing disulfide bonds (UCSS1a)
| Type | S-S bond count | Sub-typea | Examples |
|---|---|---|---|
| I | 1 | A | Brevinin, esculentin (Rana box) |
| B | Thanatin | ||
| C | Bactenecin | ||
| II | 2 | A | Ec-AMP1, lasiocepsin, Glycocin F |
| B | Protegrin, polyphemusin, CXCL1, LEAP-2 |
||
| III | 3 | A | NK-lysin, caenopore-5 |
| B | HNP-1, HBD-1, big defensins | ||
| IV | 4 | B | ASABF, NaD1, drosomycin |
| V | 5 | B | PhD1, WAMP-1a, Ec-CBP |
| VI | 6 | B | Copsin |
a
The peptides can further be classified into sub-types based on 3D structure (A: α-helical; B: β-sheet-containing (β and αβ families); C: non-αβ; D: unclassified due to an unknown 3D structure).