Table 9.
A universal classification of antimicrobial peptides
| Class | Chain linkage |
Subclass | Link type | Class symbol |
Examples |
|---|---|---|---|---|---|
| I | Linear & open chainsa |
1. One chain | None | UCLL1a | LL-37, magainins |
| 2. Two chains | None | UCLL2 | Enterocin L50 | ||
| II | Sidechain- Sidechain |
1. One chain | Cβ-S-S-Cβ (Disulfide- bond) |
UCSS1aa | Defensin-like |
| Cβ-S-Cβ (thioether) |
UCSS1ba | lantibiotics | |||
| 2. Two chains | Inter-chain Cβ-S-S-Cβ |
UCSS2a | Distinctin, halocidin, centrocin |
||
| Intra-chain Cβ-S-Cβ |
UCSS2b | Lacticin-3147, Smb | |||
| III | Sidechain- Backbone |
One chain | CO-NH amide |
UCSB1a | Microcin J25, Lariatins |
| CO-O ester | UCSB1b | Fusaricidin A | |||
| Cβ-S-Cα | UCSB1c | Thuricin CD | |||
| IV | Backbone- Backbone |
One chain | CO-NH amide |
UCBB1aa | AS-48, subtilosin A, cyclotides, θ- defenins |