Table 2.

Uniform and selected optimal dosing regimens for 5x/wk schedule of administration. Objective functions are evaluated at T = 14 d.

Regimena	ΔBb	AUCT(mg · d/L)	MT
Uniform dosing
(10, 10, 10, 10, 10, 0, 0)	−1.01	54.15	2.99
(20, 20, 20, 20, 20, 0, 0)	−1.57	108.29	3.23
Optimized dosing
(0, 30, 30, 30, 25, 0, 0)c	−1.35	124.53	2.96
(15, 10, 10, 10, 25, 0, 0)d	−1.32	75.78	3.14
(0, 25, 20, 20, 30, 0, 0)e	−1.27	102.85	2.94

^aWeekly regimen (D₀, D₁, D₂, D₃, D₄, D₅, D₆) (mg/kg).

^bΔB = B_T − B₀, B₀ = log₁₀N₀.

^cP1: Minimized (B_T, M_T).

^dP2: Minimized (B_T, AUC_T).

^eP3: Minimized (B_T, AUC_T, M_T).