Table 3.

Uniform and selected optimal dosing regimens for 7x/wk schedule of administration. Objective functions are evaluated at T = 14 d.

Regimen a	ΔBb	AUCT(mg · d/L)	MT
Uniform dosing
(10, 10, 10, 10, 10, 10, 10)	−1.64	74.75	3.28
(20, 20, 20, 20, 20, 20, 20)	−2.29	149.49	3.49
Optimized dosing
(0, 5, 30, 30, 30, 30, 30)c	−2.06	164.65	3.23
(15, 15, 15, 15, 15, 15, 15)d	−2.02	112.12	3.41
(0, 30, 20, 15, 20, 30, 20)e	−2.03	143.93	3.27

^aWeekly regimen (D₀, D₁, D₂, D₃, D₄, D₅, D₆) (mg/kg).

^bΔB = B_T − B₀, B₀ = log₁₀N₀.

^cP1: Minimized (B_T, M_T).

^dP2: Minimized (B_T, AUC_T).

^eP3: Minimized (B_T, AUC_T, M_T).