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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: JAMA Intern Med. 2015 Feb;175(2):171–177. doi: 10.1001/jamainternmed.2014.6388

Table 3.

Baseline hs-CRP and risk of fracture

Tertile hs-CRP
(mg/L)		 Patients
(n)		 No.
Fractures		 Incidence Rate
(per 100 person-
years)		 HR 95% CI ptrend*
Total Cohort
Highest ≥5.8 6102 142 1.15 1.13 0.88–1.44
Middle 3.2–5.8 5939 161 1.30 1.20 0.95–1.52
Lowest < 3.2 5761 128 1.06 Ref. Ref. 0.34
Men
Highest ≥5.4 3790 71 0.90 1.34 0.94–1.90
Middle 3.1–5.4 3502 80 1.07 1.42 1.01–1.99
Lowest < 3.1 3709 53 0.66 Ref. Ref. 0.10
Women
Highest ≥6.3 2317 71 1.58 0.97 0.69–1.36
Middle 3.6–6.3 2099 71 1.67 1.03 0.74–1.42
Lowest < 3.6 2385 85 1.82 Ref. Ref. 0.86
*

Adjusted for age (continuous), sex, blood pressure ≥140/90 mmHg or use of anti-hypertensive medications (yes/no), randomized treatment assignment, current tobacco use (yes/no), body mass index (categories: <25, 25–30, ≥30 kg/m2) exercise (categories: rarely or less than once per week, once/week, 2–6 times/week, daily), race, alcohol use (categories: ≤1–3 times/month, 1–6 times/week, 1–3 times/day, ≥4 times/day), baseline HbA1c in quartiles (<5.5, 5.5–5.7, 5.7–5.9, >5.9%) and history of previous fracture.