Table 3.
IPA was used to functionally annotate 146 genes altered on both microarray platforms in the PCP treatment group compared to the VEH control group
| Category | B-H p value | Genes, n |
|---|---|---|
| Neurological disease | 4.59E-10 | 76 |
| Genetic disorder | 6.95E-10 | 92 |
| Skeletal and muscular disorders | 6.95E-10 | 64 |
| Cell death | 1.03E-09 | 69 |
| Cancer | 5.31E-07 | 32 |
IPA identified a significant over-representation of genes implicated in neurological disorders and genetic disorders, including schizophrenia (19 genes in total; p = 9 × 10−5), after correcting for multiple comparisons with Benjamini-Hochberg (B-H) associated with PCP effects.