Table 4.
IPA was queried with 146 genes altered on both microarray platforms in the PCP treatment group compared to the VEH control group
| Ingenuity canonical pathways | B-H p value | Genes |
|---|---|---|
| Huntington's disease signaling | 4.27 × 10−7 | MAPK1, PIK3R1, UBE2S, SNAP25, CDK5R1, PRKCG, DNM1, BCL2L1, MTOR, PRKCI, PENK, STX16, NCOR2, NAPA, RASA1 |
| Melatonin signaling | 1.78 × 10−5 | PRKACB, CAMK4, PRKCI, MAPK1, RORB, PRKCG, PRKAR1A, CAMK2G |
| Neuropathic pain signaling in dorsal horn neurons | 1.78 × 10−5 | PRKACB, CAMK4, PRKCI, MAPK1, GRIA1, PIK3R1, PRKCG, PRKAR1A, CAMK2G |
| Synaptic long-term potentiation | 2.63 × 10−5 | PRKACB, CAMK4, PRKCI, MAPK1, GRIA1, PPP3CA, PRKCG, PRKAR1A, CAMK2G |
| Calcium signaling | 2.63 × 10−5 | PRKACB, CALR, CAMK4, MAPK1, GRIA1, MEF2C, ATP2A2, PPP3CA, ATP2B2, PRKAR1A, CAMK2G |
IPA canonical pathway analysis identified the following over-represented canonical pathways after correcting for multiple comparisons. B-H = Benjamini-Hochberg.