Table 7.
PCP-altered genes were normalized by coadministration of OLZ and fulfilled three critieria: significantly dysregulated in PCP-versus VEH-administered animals, significantly altered in the same direction between PCP- and PCP + OLZ-administered animals, and showed no significant difference in expression between PCP + OLZ- and VEH-administered animals
| Gene symbol | Gene title | PCP vs. VEH |
PCP vs. PCP/OLZ |
PCP/OLZ vs. VEH |
|||
|---|---|---|---|---|---|---|---|
| p value | FC | p value | FC | p value | FC | ||
| ACTB | actin, beta | 5.54E-06 | –1.29 | 1.06E-08 | –1.42 | 4.61E-02 | 1.10 |
| ACYP1 | acylphosphatase 1, erythrocyte (common) type | 4.17E-02 | –1.11 | 3.81E-02 | –1.12 | 9.66E-01 | 1.00 |
| ATP1A3 | ATPase, Na+/K+ transporting, alpha 3 polypeptide | 9.48E-04 | –1.18 | 8.75E-05 | –1.23 | 4.07E-01 | 1.04 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 1.07E-03 | –1.18 | 2.57E-03 | –1.16 | 7.45E-01 | –1.01 |
| ATP2B2 | ATPase, Ca++ transporting, plasma membrane 2 | 5.89E-04 | –1.27 | 2.92E-03 | –1.22 | 5.57E-01 | 1.04 |
| ATP6V1A | ATPase, H+ transporting, lysosomal 70 kDa, V1 subunit A | 3.35E-07 | –1.39 | 1.76E-07 | –1.41 | 8.34E-01 | 1.01 |
| C1orf61 | chromosome 1 open reading frame 61 | 2.39E-02 | –1.16 | 3.89E-02 | –1.14 | 8.25E-01 | –1.01 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | 7.64E-09 | –1.40 | 3.97E-06 | –1.28 | 4.60E-02 | –1.09 |
| CAMK2G | calcium/calmodulin-dependent protein kinase II gamma | 2.70E-03 | –1.13 | 6.50E-03 | –1.12 | 7.32E-01 | –1.01 |
| CBX3 /// LOC644101 | chromobox homolog 3 (HP1 gamma homolog, Drosophila) /// similar to chromobox homolog | 3.59E-02 | –1.14 | 2.34E-02 | –1.16 | 8.46E-01 | 1.01 |
| CNTN1 | contactin 1 | 3.62E-03 | –1.18 | 1.17E-02 | –1.15 | 6.40E-01 | –1.02 |
| CSNK1G2 | casein kinase 1, gamma 2 | 1.16E-02 | –1.15 | 9.82E-03 | –1.15 | 9.46E-01 | 1.00 |
| CTBP1 | C-terminal binding protein 1 | 5.07E-03 | –1.17 | 5.08E-03 | –1.17 | 9.99E-01 | –1.00 |
| CYP2A13 | cytochrome P450, family 2, subfamily A, polypeptide 13 | 2.92E-02 | –1.12 | 4.30E-02 | –1.11 | 8.57E-01 | –1.01 |
| GABRB3 | gamma-aminobutyric acid (GABA) A receptor, beta 3 | 3.38E-06 | –1.32 | 8.44E-04 | –1.20 | 6.71E-02 | –1.10 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 1.80E-02 | –1.13 | 2.10E-02 | –1.12 | 9.46E-01 | –1.00 |
| GDI2 | GDP dissociation inhibitor 2 | 2.20E-04 | –1.27 | 8.47E-04 | –1.24 | 6.34E-01 | –1.03 |
| KCNAB2 | potassium voltage-gated channel, shaker-related subfamily, beta member 2 | 7.22E-03 | –1.13 | 1.84E-02 | –1.11 | 6.96E-01 | –1.02 |
| KLHDC3 | kelch domain containing 3 | 2.64E-04 | –1.25 | 4.24E-07 | –1.39 | 3.78E-02 | 1.12 |
| MAP2 | microtubule-associated protein 2 | 1.60E-03 | –1.33 | 5.96E-04 | –1.37 | 7.20E-01 | 1.03 |
| MAT2A | methionine adenosyltransferase II, alpha | 6.02E-05 | –1.26 | 7.90E-05 | –1.25 | 9.27E-01 | –1.00 |
| MBP | myelin basic protein | 2.84E-03 | –1.16 | 1.19E-03 | –1.18 | 7.45E-01 | 1.01 |
| MEF2C | myocyte enhancer factor 2C | 3.59E-03 | –1.21 | 2.12E-04 | –1.29 | 3.07E-01 | 1.06 |
| NF2 | neurofibromin 2 (merlin) | 1.54E-03 | –1.24 | 7.69E-03 | –1.19 | 5.36E-01 | –1.04 |
| NOMO1 /// NOMO2 /// NOMO3 | NODAL modulator 1 /// NODAL modulator 2 /// NODAL modulator 3 | 2.19E-03 | –1.18 | 2.16E-03 | –1.18 | 9.97E-01 | 1.00 |
| NRCAM | neuronal cell adhesion molecule | 1.05E-06 | –1.34 | 3.20E-05 | –1.27 | 2.65E-01 | –1.06 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 4.56E-04 | –1.22 | 9.67E-03 | –1.15 | 2.53E-01 | –1.06 |
| PLD3 | phospholipase D family, member 3 | 1.21E-03 | –1.15 | 2.60E-03 | –1.14 | 7.76E-01 | –1.01 |
| PLP1 | proteolipid protein 1 | 1.25E-02 | –1.12 | 1.06E-02 | –1.12 | 9.47E-01 | 1.00 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 4.72E-08 | –1.36 | 7.16E-08 | –1.35 | 8.92E-01 | –1.01 |
| PRKCG | protein kinase C, gamma | 2.15E-03 | –1.17 | 1.28E-05 | –1.26 | 8.14E-02 | 1.08 |
| PTPRS | protein tyrosine phosphatase, receptor type, S | 2.50E-03 | –1.23 | 6.67E-04 | –1.26 | 6.28E-01 | 1.03 |
| RAB3A | RAB3A, member RAS oncogene family | 7.58E-05 | –1.21 | 3.18E-07 | –1.30 | 7.74E-02 | 1.08 |
| RAB6A | RAB6A, member RAS oncogene family | 3.21E-06 | –1.27 | 6.88E-04 | –1.18 | 7.55E-02 | –1.08 |
| RASA1 | RAS p21 protein activator (GTPase activating protein) 1 | 1.26E-03 | –1.18 | 6.84E-04 | –1.19 | 8.24E-01 | 1.01 |
| RGS4 | regulator of G-protein signaling 4 | 8.76E-07 | –1.31 | 1.51E-07 | –1.34 | 5.67E-01 | 1.03 |
| RHOB | ras homolog gene family, member B | 1.02E-06 | –1.36 | 6.86E-07 | –1.37 | 8.99E-01 | 1.01 |
| RORB | RAR-related orphan receptor B | 2.58E-04 | –1.25 | 6.22E-04 | –1.23 | 7.57E-01 | –1.02 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 1.83E-04 | –1.26 | 2.64E-06 | –1.36 | 1.63E-01 | 1.08 |
| SFRS3 | splicing factor, arginine/serine-rich 3 | 1.25E-06 | –1.32 | 6.48E-07 | –1.34 | 8.31E-01 | 1.01 |
| SLC3A2 | solute carrier family 3 (activators of dibasic and neutral amino acid transport) | 6.39E-03 | –1.12 | 3.09E-02 | –1.10 | 5.05E-01 | –1.03 |
| SNAP25 | synaptosomal-associated protein, 25 kDa | 4.23E-02 | –1.14 | 2.42E-02 | –1.15 | 7.97E-01 | 1.02 |
| SYN1 | synapsin I | 5.38E-04 | –1.17 | 4.61E-07 | –1.29 | 2.26E-02 | 1.10 |
| THRA | thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogen | 2.38E-02 | –1.11 | 2.77E-02 | –1.11 | 9.45E-01 | –1.00 |
| UBAP2L | ubiquitin-associated protein 2-like | 9.94E-04 | –1.22 | 3.54E-04 | –1.25 | 7.13E-01 | 1.02 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 2.40E-04 | –1.21 | 2.45E-04 | –1.21 | 9.94E-01 | –1.00 |
| UBE2S | ubiquitin-conjugating enzyme E2S | 8.75E-03 | –1.14 | 4.48E-02 | –1.10 | 4.76E-01 | –1.03 |
| VDAC1 | voltage-dependent anion channel 1 | 4.28E-02 | –1.11 | 3.18E-02 | –1.12 | 8.91E-01 | 1.01 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pol | 7.41E-04 | –1.20 | 1.60E-02 | –1.14 | 2.38E-01 | –1.06 |
| ZNF238 | zinc finger protein 238 | 4.36E-04 | –1.20 | 4.49E-04 | –1.20 | 9.92E-01 | –1.00 |
This table shows the 50 normalized genes that fulfilled three criteria on the HU6800 array. FC = Fold change.