Table 2.
Counts, incidence rates and incidence risk ratio of adverse events between males circumcised at 3 different age groups. Charge Data Master 1 (CDM1), CDM2, and outpatient data, Unites States 2001 – 2010
| Adverse events (Italicized = Potentially serious) |
Age at circumcision | Count among circumcised males (Incidence per million circumcisions; 95% CI) |
Incidence Risk Ratios (95% CI) |
Incidence Rate Difference (95% CI) |
|---|---|---|---|---|
| Amputationsa | < 1 year old | 8(5.99;3.00–11.99) | Reference group | Reference group |
| 1 – 9 years old | 0 | N.A. | N.A. | |
| ≥ 10 years old | 63(1678.07; 1311.17 – 2147.64) | 81.29(33.44 – 197.58) | 420.94(212.12 – 629.75) | |
| Amputation of penisa | < 1 year old | 0 (0) | Reference group | Reference group |
| 1 – 9 years old | 0 (0) | N.A. | N.A. | |
| ≥ 10 years old | 45 (1198.62; 895.09 – 1605.08) | N.A. | 45 (1198.62; 895.09 – 1605.08) | |
| Amputation of penis, partiala | < 1 year old | 7(5.24;2.50 – 11.00) | Reference group | Reference group |
| 1 – 9 years old | 0 | N.A. | N.A. | |
| ≥ 10 years old | 16(426.18; 261.12 – 695.58) | 81.29(33.44 – 197.58) | 420.94(212.12 – 629.75) | |
| Amputation of penis, completea | < 1 year old | 1 (0.75; 2.50 – 11.01) | Reference group | Reference group |
| 1 – 9 years old | 0 (0) | N.A. | N.A. | |
| ≥ 10 years old | 2 (53.27; 26.11 – 69.55) | 71.03 (6.44 – 783.35) | 52.52(−21.32–126.37) | |
| Woundsa | < 1 year old | 87 (65.25; 52.88 – 80.50) | Reference group | Reference group |
| 1 – 9 years old | 11 (390.11; 216.06 – 704.34) | 5.97 (3.19 – 11.19)) | 324.95(94.05 – 555.86) | |
| ≥ 10 years old | 113 (3009.88; 2503.77 – 3618.28) | 46.12 (34.88 – 60.99)) | 2944.7(2390.4 – 3499.0) | |
| Open wound of penis w/out mention of complicationsa | < 1 year old | 87 (65.25; 52.88 – 80.50) | Reference group | Reference group |
| 1 – 9 years old | 11 (390.11; 216.06 – 704.34) | 5.97 (3.19 – 11.19) | 324.95(94.05 – 555.86) | |
| ≥ 10 years old | 113 (3009.88; 2503.77 – 3618.28) | 46.12 (34.88 – 60.99) | 2944.7(2390.4 – 3499.0) | |
| Correctional proceduresd | < 1 year old | 4018(3009.3;2917.8 – 3103.7) | Reference group | Reference group |
| 1 – 9 years old | 2947 (104515;101004 – 108147) | 34.73(33.17 – 36.37) | 101505(97933 – 105077) | |
| ≥ 10 years old | 1219 (32469;30725 – 34313) | 10.79(10.13 – 11.49) | 29460(27665 – 31255) | |
| Suture of laceration of penisa | < 1 year old | 314 (235.49; 210.84 – 263.03) | Reference group | Reference group |
| 1 – 9 years old | 25 (886.61; 599.20 – 1311.90) | 3.76 (2.50 – 5.65) | 651.44(303.07 – 999.82) | |
| ≥ 10 years old | 55 (1464.98; 1124.97 – 1907.76) | 6.22 (4.67 – 8.28) | 1229.8(842.05 – 1617.6) | |
| Suture of laceration of penisd | < 1 year old | 322 (241.49; 216.51 – 269.36) | Reference group | Reference group |
| 1 – 9 years old | 27 (957.74; 656.78 – 1396.03) | 3.96 (2.67 – 5.870 | 716.38(354.41 – 1078.4) | |
| ≥ 10 years old | 61 (1624.80; 1264.45 – 2087.84) | 6.72 (5.11 – 8.84) | 1383.6(975.37 – 1791.9) | |
| Replantation of penisa | < 1 year old | 4(3.00;1.12 – 7.98) | Reference group | Reference group |
| 1 – 9 years old | 0 | N.A. | N.A. | |
| ≥ 10 years old | 0 | N.A. | N.A. | |
| Replantation of penisd | < 1 year old | 4(3.00;1.12 – 7.98) | Reference group | Reference group |
| 1 – 9 years old | 0 | N.A. | N.A. | |
| ≥ 10 years old | 0 | N.A. | N.A. | |
| Other repair of penisc | < 1 year old | 841 (630.74; 589.53 – 674.83) | Reference group | Reference group |
| 1 – 9 years old | 468 (16598.00; 15171.34 – 18157.74) | 26.31 (23.51 – 29.44) | 15968(14476 – 17459) | |
| ≥ 10 years old | 394 (10495.00; 9512.83 – 11577.76) | 16.63 (14.76 – 18.74) | 9864.8(8833.1 – 10896) | |
| Other repair of penisd | < 1 year old | 1213 (909.74; 859.98 – 962.38) | Reference group | Reference group |
| 1 – 9 years old | 471 (16704.00; 15273.04 – 18268.81) | 18.36 (16.51 – 20.40) | 15795(14299 – 17292) | |
| ≥ 10 years old | 399 (16628; 9639.56 – 11717.37) | 11.68 (10.43 – 13.07) | 9719.3(8680.8 – 10758) | |
| Division of penile adhesionsd | < 1 year old | 841 (630.74; 589.53 – 674.83) | Reference group | Reference group |
| 1 – 9 years old | 1203 (42664.00; 40369.23 – 45089.44) | 67.64 (61.98 – 73.81) | 42034(39675 – 44394) | |
| ≥ 10 years old | 489 (13025.00; 11927.20 – 14223.97) | 20.65 (18.48 – 23.07) | 12395(11247 – 13543) | |
| Lysis or excision of penile post-circumcision adhesionsd | < 1 year old | 685 (513.74; 476.68 – 553.68) | Reference group | Reference group |
| 1 – 9 years old | 369 (13086.00; 11825.03 – 14482.52) | 25.47 (22.45 – 28.89) | 12573(11246 – 13901) | |
| ≥ 10 years old | 116 (3089.79; 2576.43 – 3705.43) | 6.01 (4.94 – 7.32) | 2576.8(2014.0 – 3139.5) | |
| Repair incomplete circumcisiond | < 1 year old | 953 (714.74; 670.79 – 761.57) | Reference group | Reference group |
| 1 – 9 years old | 877 (31103.00; 29140.98 – 33196.26) | 43.51 (39.73 – 47.65) | 30389(28362 – 32416) | |
| ≥ 10 years old | 154 (4101.96; 3503.81 – 4802.22) | 5.73 (4.84 – 6.80) | 3388.2(2740.1 – 4036.3) | |
| Disordersa | < 1 year old | 17 (12.73; 7.92 –20.48) | Reference group | Reference group |
| 1 – 9 years old | 0 | N.A. | N.A. | |
| ≥ 10 years old | 9 (239.73; 124.74 – 460.70) | 18.83 (8.39 – 42.24) | 226.99 (70.27 – 383.71) | |
| Vascular disorders of Penisa | < 1 year old | 17 (12.73; 7.92 –20.48) | Reference group | Reference group |
| 1 – 9 years old | 0 | N.A. | N.A. | |
| ≥ 10 years old | 9 (239.73; 124.74 – 460.70) | 18.83 (8.39 – 42.24) | 226.99 (70.27 – 383.71) | |
| Infectionsa | < 1 year old | 18 (13.48; 8.49 –21.40) | Reference group | Reference group |
| 1 – 9 years old | 0 | N.A. | N.A. | |
| ≥ 10 years old | 0 | N.A. | N.A. | |
| Staphylococcal scalded skin syndrome / Ritter’s diseasea | < 1 year old | 18 (13.48; 8.49 –21.40) | Reference group | Reference group |
| 1 – 9 years old | 0 | N.A. | N.A. | |
| ≥ 10 years old | 0 | N.A. | N.A. | |
| Inflammationsa | < 1 year old | 470 (352.01;321.59 – 385.31) | Reference group | Reference group |
| 1 – 9 years old | 191 (6773.77;5880.97 – 7802.11) | 16.45 (13.93 – 19.43) | 6421.8(5463.8 – 7379.7) | |
| ≥ 10 years old | 673 (17926.11;16632.98 – 19319.78) | 83.05 (74.11 – 93.07) | 17574(16232 – 18917) | |
| Other inflammatory disorders of penis / cellulites penisa | < 1 year old | 161 (120.74; 103.46 – 140.91) | Reference group | Reference group |
| 1 – 9 years old | 111 (3936.58; 3269.54 – 4739.72) | 32.60 (25.60 – 41.50) | 3816.0(3084.9 – 4547.1) | |
| ≥ 10 years old | 508 (13531.00; 12411.52 – 14751.77) | 112.06 (93.88 – 133.75) | 13411(12242 – 14579) | |
| Edema of penisa | < 1 year old | 309 (231.74; 207.29 – 259.07) | Reference group | Reference group |
| 1 – 9 years old | 80 (2837.18; 2279.58 – 3531.17) | 12.24 (9.57 – 15.65) | 2605.8(1984.4 – 3227.1) | |
| ≥ 10 years old | 165 (4394.96; 3774.28 – 5117.70) | 18.96 (15.70 – 22.90) | 4163.5(3493.9 – 4833.2) | |
| Stricturesb | < 1 year old | 1(0.75;0.11 – 5.32) | Reference group | Reference group |
| 1 – 9 years old | 0 | N.A. | N.A. | |
| ≥ 10 years old | 1(26.64;3.75 – 189.09) | 35.56(2.22 – 568.60) | 25.89(−26.34 – 78.11) | |
| Stricture of male genital organsb | < 1 year old | 1(0.75;0.11 – 5.32) | Reference group | Reference group |
| 1 – 9 years old | 0 | N.A. | N.A. | |
| ≥ 10 years old | 1(26.64;3.75 – 189.09) | 35.56(2.22–568.60) | 25.89(−26.34 – 78.11) | |
| Bleedinga | < 1 year old | 1998(1496.4;1432.3 – 1563.5) | Reference group | Reference group |
| 1 – 9 years old | 279(9894.7;8804.3 – 11120) | 6.61(5.84 – 7.49) | 8398.2(7241.1 – 9555.4) | |
| ≥ 10 years old | 332(8843.2; 7945.1 – 9842.8) | 5.91(5.26 – 6.63) | 7346.8(6397.5 – 8296.1) | |
| Intra-operative bleedinga | < 1 year old | 1779 (1334.23; 1273.69 – 1397.65) | Reference group | Reference group |
| 1 – 9 years old | 249 (8830.72; 7803.55 – 9993.10) | 6.61 (5.80 – 7.55) | 7498.3(6404.6 – 8592.1) | |
| ≥ 10 years old | 304 (8097.38; 7239.73 – 9056.62) | 6.06 (5.37 – 6.85) | 6765.0(5856.3 – 7673.7) | |
| Hemorrhage controla | < 1 year old | 200 (149.99; 130.58 – 172.29) | Reference group | Reference group |
| 1 – 9 years old | 27 (957.54; 656.78 – 1396.03) | 6.38 (4.27 – 9.53) | 807.76(446.14 – 1169.4) | |
| ≥ 10 years old | 27 (719.17; 714.17 – 1360.00) | 4.79 (3.20 – 7.16) | 569.38(297.41 – 841.35) | |
| Suture of arterya | < 1 year old | 19(14.23; 9.08 – 22.31) | Reference group | Reference group |
| 1 – 9 years old | 3(106.39;34.32 – 329.86) | 7.48(2.21 – 25.26) | 92.16(−28.40 – 212.72) | |
| ≥ 10 years old | 1(26.64;3.75 – 189.09) | 1.87(0.25 – 13.98) | 12.41(−40.19 – 65.00) |
a
Risk window defined for 28 days post-circumcision
b
Risk window defined for 180 days post-circumcision
c
Risk window defined for 365 days post-circumcision
d
Risk window defined for 1200 days post-circumcision
Note: Adverse events that were not encountered in this analysis, i.e. had a count of zero, were not presented to reduce the length of the table. These are: repair and plastic operation on penis.
CI: confidence interval
N.A.: not applicable