Table 3.
Detailed residue-residue contacts in binding of Bcl-xL with Bak, HBS2a and HBS2b.
| Bcl-xL | Bak | HBS 2a | HBS 2b |
|---|---|---|---|
| Gly572 | - | Gln125, Gln129 | Gln125, Val126, Glu129 |
| Gln573 | Gln111 | Gln111 | Gln111 |
| Val574 | Gln111, Leu112, Ser122, Gln125, Val126, Glu129, Phe146 | Tyr101, Leu108, Gln111, Leu112, Val126, Phe146 | Tyr101, Gln111, Leu112, Val126, Phe146 |
| Gly575 | Val126, Glu129,Leu130 | Gln125, Val126, Glu129, Leu130 | Val126, Glu129, Leu130 |
| Arg576 | Glu129 | Glu129 | Glu129 |
| Gln577 | Tyr101, Phe105 | Tyr101, Phe105, Gln111 | Tyr101, Phe105, Gln111 |
| Leu578 | Phe97, Tyr101, Leu108, Leu126, Leu130, Ala142, Phe146 | Phe97, Tyr101, Leu108, Leu130, Ala142, Phe146 | Phe97, Tyr101, Leu108, Leu126, Leu130, Ala142, Phe146 |
| Ala579 | Glu129, Leu130, Arg139 | Glu129, Leu130, Arg139 | Glu129, Leu130, Arg139 |
| Ile580 | - | Phe105 | Phe105 |
| Ile581 | Phe97, Arg100, Tyr101 | Phe97, Arg100, Tyr101, Ala104, Phe105 | Phe97, Arg100, Tyr101, Ala104, Phe105 |
| Gly582 | Phe97, Gly138, Arg139 Ala142 | Phe97, Leu130, Gly138, Arg139, Ala142 | Phe97, Gly138, Arg139, Ala142 |
| Asp583 | Gly138, Arg139 | Asn136, Arg139 | Arg139, Arg204 |
| Asp584 (KAC for HBS2b) | Arg100, Arg204 | Arg100 | Arg100, Ala104, Arg204, His215 |
| Ile585 | Ala93, Glu96, Phe97, Arg100, Gly138, Val141, Ala200 | Ala93, Glu96, Phe97, Arg100, Gly138, Val141, Ala142, Tyr195 | Glu96, Phe97, Arg100, Gly138, Val141, Ala142, Tyr195, Ala200 |
| Asn586 | Trp137, Gly138 | Gly138, Leu194, Tyr195, Asn136, Trp137, Arg139 | Gly138, Leu194, Tyr195, Ala200, Arg204 |
| Arg587 | Ser203 | Leu194, His214, His215 | Leu194, Tyr195, Gln207 |
| NH2 terminal | Ala164, Ser167 | Leu158, His178, His179 | Tyr159, Ala164 |