Fig 6. Plague-free 5XFAD mice and the amyloid nature of plaques in transgenic mice.

A, Age-dependent decrease of percentage of plaque-free transgenic 5XFAD mice treated with YB-1. Abscissa, the age of mice; ordinata, percentage of plaque-free mice. B, Plaques in the brain of Tg mice contain β-amyloid. In brain slides, β-amyloid was stained with monoclonal Anti-Human β Amyloid Protein antibody (1), plaques were stained with Thioflavin S (2) as described under Materials and Methods. (3), merged staining.