Table 1. The effect of intranasally injected full-length YB-1 on neuron density and the morphofunctional state of neurons in the temporal cortex and hippocampus of OBX mice.
| Brain | Group | Neuron density | Normal neurons, | Pathological neurons, % | ||
|---|---|---|---|---|---|---|
| region | % | Pyknosis | Cytolysis | Vacuolization | ||
| Temporal cortex | SO+saline (n = 5) | 1204.86±21.94 | 82.65±0.4 | 3.58±0.27 | 12.25±0.38 | 1.4±0.16 |
| OBX+saline (n = 5) | 1124.07±16.51** | 57.27±1.06*** | 15.03±0.43*** | 22.03±0.78*** | 5.67±0.35*** | |
| OBX+YB-1 (n = 9) | 1262.04±24.94+++ | 82.27±0.64+++ | 2.6±0.24**+++ | 13.03±0.55+++ | 2.1±0.23**+++ | |
| Hip CA1-CA2 | SO+saline (n = 5) | 2797.22±24.37 | 86.65±0.54 | 2.03±0.23 | 9.95±0.43 | 0.95±0.17 |
| OBX+saline (n = 5) | 2603.70±25.69*** | 67±0.75*** | 7.73±0.32*** | 21.37±0.68*** | 3.93±0.23*** | |
| OBX+YB-1 (n = 9) | 2685.19±26.78**+ | 78.03±0.64***+++ | 3.7±0.24***+++ | 15.7±0.60***+++ | 2.53±0.24***+++ | |
| Hip CA3-CA4 | SO+saline (n = 5) | 2129.86±29.49 | 84.9±0.6 | 2.18±0.25 | 11.5±0.52 | 1.43±0.17 |
| OBX+saline (n = 5) | 1936.11±20,24*** | 64.07±0.81*** | 6.83±0.22*** | 24.27±0.63*** | 4.83±0.25*** | |
| OBX+YB-1 (n = 9) | 1993,52±15,11***+ | 73,43±0,46***+++ | 5,1±0,32***+++ | 17,23±0,34***+++ | 4,23±0,29*** | |
The two-tail t-test p-values for SO mice are *p < 0.05; **p < 0.01; ***p < 0.001, and those for OBX mice are +p < 0.05; ++p < 0.01; +++p <0.001.