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. Author manuscript; available in PMC: 2015 Sep 22.
Published in final edited form as: Nat Rev Endocrinol. 2014 Aug 19;10(10):582–591. doi: 10.1038/nrendo.2014.143

Figure 1.

Figure 1

Overview of thyroid hormone action. T3 enters the cell via thyroid hormone transporters, or is generated locally by cytoplasmic deiodinases (not shown). In the nucleus T3 binds to THR-containing dimers, which bind to genomic TREs to regulate gene transcription. Abbreviations: RXR, retinoic acid receptor; THR, thyroid hormone receptor; TRE, thyroid-hormone responsive element.