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. 2015 Sep 22;11(9):e1005149. doi: 10.1371/journal.ppat.1005149

Fig 1. APOBEC3G protects chimpanzees from most SIV cross-species infections.

Fig 1

A, Phylogenetic analysis of Vif proteins from different primate lentiviruses as described in the Methods. B, Single-round infectivity assay performed in the presence or absence of chimpanzee APOBEC3G; infectivity in the absence of APOBEC3G was normalized to 100%. The graphs show the infectivity values for the average of six to nine infections; error bars indicate the SD from the mean of these replicates. The infectivity of HIV-1ΔVif (white, negative control), and HIV-1ΔVifΔEnvLuc2 plasmid with vif from SIVcpzPtsTan3 or SIVcpzPttGab1 (black, positive controls), or vif from SIVs from the given primate species (grey bars) were tested. Each of the Vif proteins was fully capable of antagonizing at least one APOBEC3 protein using identical proviral expression constructs to those in Fig 1B ([4,17,20] and Fig 2).