Table 1. All viruses that naturally jumped the species barrier had some capacity to antagonize the new species APOBEC3G.
Sensitivity of APOBEC3G (from the recipient host species) to the SIV Vif protein (from the virus that crossed the species barrier); infectivity of viruses produced in the presence of APOBEC3G is reported as a percentage, relative to infectivity in the absence of APOBEC3G (100%).
| SIV Vif Isolates a | APOBEC3G b | Relative infectivity of viruses c | Origin of… d | Reference e |
|---|---|---|---|---|
| SIVrcm | Chimpanzee | 17% | SIVcpz | Fig 1B |
| SIVmus | Chimpanzee | 25% | SIVcpz | Fig 1B |
| SIVcpz | Human | 73% | HIV-1 | Etienne et al. 2013 |
| SIVcpz | Gorilla | Minimal | SIVgor | Letko et al. 2013, D’Arc et al. 2015 |
| SIVgor | Human | ~85% | HIV-1 | Letko et al. 2013 |
| SIVsmm | Macaques | 90% | SIVmac | Compton et al. 2013 |
| SIVsmm | Human | 100% | HIV-2 | Compton et al. 2013 |
| SIVver | Baboon | 86% | SIVver-bab | S2 Fig |
| SIVsab | Patas | 71% | SIVsab-pat | S2 Fig |
a, Virus from which the vif gene was taken. Vif proteins are from viruses that crossed to a new host species.
b, Host species from which APOBEC3G was taken. APOBEC3G proteins are from recipient host species.
c, Infectivity of viral constructs produced in the presence of APOBEC3G (relative to no APOBEC3G).
d, Virus that resulted from the cross-species transmission event(s).