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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Vascul Pharmacol. 2015 Apr 25;73:20–31. doi: 10.1016/j.vph.2015.04.005

Figure 6. Inhibition of HDACs with apicidin suppresses neonatal hypoxia-induced pulmonary hypertension.

Figure 6

(A) Schematic of the study design. (B) C57BL/6 mouse pups were exposed to normoxia or 11% hypoxia from birth for two weeks and administered either apicidin (2 mg/kg, i.p.) or vehicle control three days per week from P5. RV hypertrophy was assessed at P14. (C) Ratio of right ventricular weight to body weight was measured at P14. (D) Representative photomicrographs of pulmonary arteries at P14 in mouse pups exposed to normoxia or hypoxia and given either vehicle or apicidin. Scale bar = 50 μm. NV=normoxia vehicle HV=hypoxia vehicle HT=hypoxia apicidin-treated (E) Quantitative analysis of wall thickness of pulmonary arteries at P14 of mice in normoxia or hypoxia and given either vehicle or apicidin. * p<0.05 compared with normoxia vehicle. # p<0.05 compared with hypoxia vehicle group.