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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Vascul Pharmacol. 2015 Apr 25;73:20–31. doi: 10.1016/j.vph.2015.04.005

Figure 7. Chronic neonatal hypoxia modulates lung DNA methylation in IGF-1 promoter region.

Figure 7

(A) Location of CpG sites along proximal mouse IGF-1 promoter region. (B) Genomic DNA isolated from normoxic and hypoxic lungs was analyzed for cytosine methylation at multiple sites along the mIGF-1 promoter region in the lungs. * p<0.05 compared to normoxia control. (C) HDAC inhibition with apicidin normalizes hypoxia-induced elevation of cytosine methylation at CpG1 site (position 87857993) along pulmonary IGF-1 promoter region (Chr10). * p<0.05 compared to normoxia controls. # p<0.05 compared to hypoxia vehicle controls.