Table.

Gene definitions and functions.

Gene	Up or down regulated	Function	Citations
NQO1 NAD(P)H dehydrogenase, quinone 1	Up	This gene encodes a cytoplasmic 2- electron reductase. It functions to reduce quinones to hydroquinones. Dysregulation of NQO1 expression is reported in lung cancer.	Bey et al., 2007; Iskander et al., 2008;
CRYAB crystallin, alpha B	Up	CRYAB protein product holds its target protein in large aggregates. Overexpression of the CRYAB gene promotes the progression of non-small cell lung cancer.	Qin et al., 2014
S100A4 S100 calcium binding protein A4	Up	This protein is involved in cell cycle progression, differentiation, and other cellular processes. Dysfunction of S100A4 gene has been reported to increase the incidence of lung carcinoma.	Naaman et al., 2004
SPK2 S-phase kinase-associated protein 2	Up	Spk2 protein plays an intricate role in S- phase of the cell cycle and is an essential element of the cyclin A-CDK2 kinase. Increased levels of Spk2 enhances the growth of small cell lung cancers.	Yokoi et al., 2002
CD74 Major histocompatibility complex, class II	Up	Patients with Chronic lymphocytic leukemia (CLL) display an increased expression of CD74. High expression of CD74 was associated with advanced stages of CLL.	Butrym et al., 2013
HOXB5 Homeobox 5	Down	The encoded protein is involved in gut and lung development. This gene has been associated with acute myeloid leukemia (AML).	Liu et al., 2011; Cai et al., 2012
MST4 Serine/threonine protein kinase 26	Up	Up-regulation of this gene is involved in the differentiation of NB4 cells, an acute promyelocytic leukemia cell line, and expression is also found in Jurkat cells, an acute T-cell leukemia cell line	Hattori et al., 2007; Lin et al., 2001
CSF3 Colony stimulating factor 3	Up	Up-regulation of this protein increases proliferation of HL-60 cells, which are a promyelocytic leukemia cell line.	Yamaguchi et al., 1999
CDNK1A cyclin-dependent kinase inhibitor 1A	Down	This gene encodes p21, which acts as a regulator of cell cycle progression at G1 by binding to and inhibiting the activity of cyclin-CDK2 complexes. Its role in carcinogenesis may be due to its influence on apoptosis following caspase activation.	Hata et al., 2005; Nakagawa et al., 2005
TGF1B transforming growth factor, beta 1	Down	TGF1B encodes a cytokine that regulates proliferation, differentiation, adhesion, migration, and other functions in many cell types. Presence of Tgf1b protein decreases cellular proliferation in lymphoma cell lines, Mac-2A and DB cells. Repressing TGF1B mRNA levels by siRNA increased proliferation of HL60 cells, a leukemia cell line.	Chen et al., 2007; Turley et al., 1996; Cohen et al., 2009