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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2015 Jul 17;288(1):40–51. doi: 10.1016/j.taap.2015.07.013

Figure 7. Developmental arsenic exposure differentially alters acetylation of histone 3 lysine 9 (H3K9ac) and its associated chromatin modifying proteins in the frontal cortex compared to the dentate gyrus.

Figure 7

Unlike the pattern of H3K4me3 the male dentate gyrus and frontal cortex, DAE decreases levels of acetylation of H3K9 (H3K9ac) in (A) the adult male frontal cortex with concurrent decreased protein expression of (B, left) GCN5 and (B, right) PCAF, both histone acetyltransferases capable of H3K9 acetylation. Similar to observations in the male dentate gyrus, DAE does not impact (C) HDAC1 or HDAC2 protein expression in the male frontal cortex. *p<.05; **p<.01