Table 1. miRNA-10b expression correlates with survival and recurrence in human medulloblastoma patient samples.
Human biopsy samples were subjected to RNA extraction followed by generation of cDNA, and subjected to RT-PCR for analysis of miRNA-10b expression. The fold expression of miRNA-10b was compared to the normal cerebellar control. miRNA-10b expression was correlated with the patients’ clinical and pathological history.
| Patient # | Gender | Age at surgery | Time to recurrence | #Recurrences | Time to Death | MIB-1 | Pathologic subtype | Molecular subgroup | miRNA-10b expression |
|---|---|---|---|---|---|---|---|---|---|
| 1 | F | 3y10m | 16m | 4 | 3y11m | 35% | Classic | Group 3 | 1.947 |
| 2 | M | 34m | 13m | 1 | 2y1m | 45% | Desmoplastic | SHH | 0.0816 |
| 3 | M | 25 | 53m | 1 | 5y4m | 80% | Desmoplastic | SHH | 1.043 |
| 4 | M | 12 | 31m | 1 | 4y9m | 43.60% | Classic | Group 4 | 0.414 |
| 5 | F | 16 | 27m | 4 | 7y5m | 57.10% | Classic | Wnt | 198.400 |
| 6 | M | 7y9m | none | 0 | 60% | Desmoplastic | Group 4 | 2.472 | |
| 7 | F | 2y11m | none | 0 | 65.40% | Desmoplastic | Wnt | 13.056 | |
| 8 | M | 13m | none | 0 | 40–50% | Desmoplastic | SHH | 0.233 | |
| 9 | M | 4y5m | 16m | 1 | 1y8m | 33.30% | Classic | Group 3 | 7.223 |
| 10 | M | 8m | 14m | 3 | 3y2m | 36.10% | Desmoplastic | SHH | 0.260 |
| 11 | M | 16 | none | 0 | 34.32% | Classic | Group 4? | 52.740 | |
| 13 | F | 26 | 6m | 5 | 4y8m | 30% | Classic | 589.254 | |
| 14 | M | 17m | 4m | 2 | 8m | 40% | Classic | 0.448 |