Fig 3. Serum creatinine, urine output, urine protein, albuminuria, weight and blood pressure after nephrotoxic nephritis in STC1 knockdown (STC1 shRNA Tg) compared with control mice (scrambled shRNA Tg).

Following nephrotoxic nephritis and compared to baseline, serum creatinine was numerically higher in STC1 knockdown kidneys relative to controls (3-fold vs. 2.5-fold); urine output and proteinuria where numerically lower (2.1-fold vs. 2.85-fold and 12-fold vs. 17-fold, respectively), but the differences between the groups were not statistically significant; albuminuria was increased to a similar degree. Blood pressure and weight were higher following nephrotoxic nephritis in STC1 knockdown kidneys compared to control kidneys.