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. 2015 Sep 22;10(9):e0137716. doi: 10.1371/journal.pone.0137716

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Fig 6 — (A) After a 2 h incubation with rVλ6Wil fibrils or monomer, cellular ATP levels, as detected by luminescence (black bars), were not significantly reduced relative to the PBS-treated control. A decrease in MTT reduction (gray bars) was observed in the presence of fibrils (n = 3). (B) Oxygen consumption rate was significantly higher in AC10 cells (p < 0.05) treated with 1μM rVλ6Wil fibrils as compared to treatment with PBS or rVλ6Wil monomer protein (n = 6 wells). (C) Cardiomyocytes labeled with DCFH-DA exhibited a dose-dependent increase in ROS production after 24 h of exposure to rVλ6 Wil fibrils (n = 3).