Table 3.

Multivariate Analysis of Overall Mortality Risk

Characteristics	Total (N = 2105)			Early stage (N = 587)		Advanced stage (N = 1220)
	N	HR	95 % CI	HR	95 % CI	HR	95 % CI
Treatment status
Treated	1320	ref		ref		ref
Not treated	785	1.39	1.23–1.57	1.37	1.04–1.80	1.46	1.26–1.69
Age at diagnosis
18–54	324	ref		ref		ref
55–64	684	1.04	0.88–1.23	0.80	0.50–1.25	1.11	0.91–1.34
65–74	606	1.23	1.04–1.46	1.06	0.67–1.68	1.21	0.99–1.48
≥ 75	491	1.20	0.99–1.44	1.17	0.72–1.88	1.20	0.95–1.50
Race
Caucasian (ref)	1513	ref		ref		ref
African American	223	0.90	0.77–1.07	0.95	0.66–1.38	0.87	0.72–1.08
Asian/Pacific islander	221	0.80	0.66–0.96	0.67	0.41–1.09	0.84	0.68–1.06
Hispanic	52	1.16	0.83–1.63	2.64	1.06–6.62	0.99	0.64–1.53
Other/Unknown	96	0.88	0.58–1.32	1.04	0.22–4.96	1.08	0.56–2.07
Sex
Male	1359	ref		ref		ref
Female	746	0.89	0.79–1.00	0.75	0.56–0.99	0.88	0.76–1.01
Stage
I	293	ref
II	115	1.21	0.89–1.64
IIIA	179	1.65	1.28–2.12
IIIB/IV	1220	2.64	2.17–3.22
Missing/Unknown	298	1.73	1.35–2.22
Histology
Squamous	442	ref		ref		ref
Adenocarcinoma	869	0.96	0.83–1.11	0.60	0.44–0.82	1.02	0.85–1.22
Large cell	41	0.95	0.65–1.39	0.62	0.22–1.75	1.00	0.63–1.58
Other	753	1.15	1.00–1.32	0.82	0.61–1.10	1.19	1.00–1.42
# of Comorbidities
0	994	ref		ref		ref
1–3	591	1.08	0.95–1.22	1.02	0.77–1.37	1.08	0.93–1.25
> 3	520	1.36	1.19–1.54	1.39	1.03–1.87	1.37	1.17–1.61
Tobacco history
No	205	ref		ref		ref
Yes	1687	1.27	1.04–1.55	1.16	0.72–1.85	1.37	1.08–1.74
Unknown	213	1.08	0.78–1.51	1.02	0.45–2.31	1.17	0.78–1.77

Model also includes family history, marital status, region, and alcohol history