Table 1.
Genes known from congenital long QT syndrome, investigated in drug-induced long QT syndrome or torsade de pointes
| cLQTS type | Gene abbreviation | Gene name [110] | Gene protein product [9] | Association founda | |
|---|---|---|---|---|---|
| Yes | No | ||||
| cLQTS1 | KCNQ1 | Potassium channel, voltage gated KQT-like subfamily Q, member 1 gene | IKs channel alpha-subunit | 3 | 4 |
| cLQTS2 | KCNH2 | Potassium channel, voltage gated eag-related subfamily H, member 2 | IKr channel alpha-subunit | 9 | 4 |
| cLQTS3 | SCN5A | Sodium channel, voltage gated, type V alpha-subunit | INa channel alpha-subunit | 3 | 4 |
| cLQTS4 | ANK2 | Ankyrin 2, neuronal | 1 | 1 | |
| cLQTS5 | KCNE1 | Potassium channel, voltage gated subfamily E regulatory beta-subunit 1 | IKs channel beta-subunit | 4 | 3 |
| cLQTS6 | KCNE2 | Potassium channel, voltage gated subfamily E regulatory beta-subunit 2 | IKr channel beta-subunit | 2 | 6 |
| cLQTS7 | KCNJ2 | Potassium channel, inwardly rectifying subfamily J, member 2 | IKl alpha-subunit | 0 | 3 |
| cLQTS8 | CACNA1C | Calcium channel, voltage-dependent, L type, alpha-1C subunit | ICaL channel alpha-subunit | 2 | 1 |
| cLQTS9 | CAV3 | Caveolin-3 | 0 | 2 | |
| cLQTS10 | SCN4B | Sodium channel, voltage gated, type IV beta-subunit | INa channel beta-subunit 4 | 1 | 1 |
| cLQTS11 | AKAP9 | A kinase anchor protein 9 | 1 | 2 | |
| cLQTS12 | SNTA1 | Syntrophin, acidic 1 | 1 | 1 | |
| cLQTS13 | KCNJ5 | Potassium channel, inwardly rectifying subfamily J, member 5 | IKACh channel alpha-subunit | 0 | 1 |
cLQTS congenital long QT syndrome
aNumber of studies that did or did not find an association with the corresponding gene