Table 1.

Subsets of the OMOP reference standard used in the three experiments

	Reference Set 1 FAERS and NYP/CUMC EHR		Reference Set 2 FAERS and GE EHR		Reference Set 3 FAERS and claims data
	P	N	P	N	P	N
Acute renal failure	16	37	21	48	21	51
Acute liver injury	52	16	75	30	77	32
Acute myocardial infarction	10	28	33	51	33	58
Upper GI bleed	17	38	24	57	24	63
Total	95	119	153	186	155	204

EHR electronic health record, FAERS FDA Adverse Event Reporting System, GE EHR GE Healthcare MQIC (Medical Quality Improvement Consortium) database, N negative controls, NYP/CUMC New York Presbyterian Hospital at Columbia University Medical Center, OMOP Observational Medical Outcomes Partnership, P positive controls in the reference standard