Table 3.

AUC for FAERS and NYP/CUMC EHR before and after confounding adjustment

ADR	FAERS		NYP/CUMC EHR
	Unadjusted	Adjusted	Unadjusted	Adjusted
Acute renal failure	0.50	0.89*	0.58	0.61
Acute liver injury	0.50	0.70*	0.55	0.45
Acute myocardial infarction	0.48	0.65*	0.44	0.53
Upper GI bleed	0.49	0.83*	0.48	0.54
Total	0.49	0.75*	0.55	0.51

Unadjusted: signal scores (one-sided p values) are not adjusted for the confounding effect

Adjusted: signal scores (one-sided p values) are adjusted for the confounding effect

The bold values indicate the highest AUC performance but not necessarily significantly higher than comparators except for those also marked with * where the performance difference is statistically significant

ADR adverse drug reaction, AUC area under the receiver operator characteristics curve, EHR Electronic health record, FAERS FDA Adverse Event Reporting System, NYP/CUMC New York Presbyterian Hospital at Columbia University Medical Center