Table 6.
ADR signals detected only using the combined GE and FAERS system and their one-sided p values in three systems
| Medication | ADR | Ground Truth | FAERS | GE | Combined system |
|---|---|---|---|---|---|
| Piroxicam | ARF | 1 | 0.299 | 0.432 | 0.043 |
| Amoxapine | AMI | 1 | 0.076 | 0.118 | 0.007 |
| Diflunisal | AMI | 1 | 0.109 | 0.192 | 0.007 |
| Eletriptan | AMI | 1 | 0.682 | 0.072 | 0.034 |
| Nabumetone | AMI | 1 | 0.079 | 0.494 | 0.035 |
| Nelfinavir | AMI | 0 | 0.292 | 0.263 | 0.044 |
| Zolmitriptan | AMI | 1 | 0.224 | 0.381 | 0.034 |
| Ketorolac | GIB | 1 | 0.425 | 0.069 | 0.041 |
ADR adverse drug reaction, AMI acute myocardial infarction, ARF acute renal failure, FAERS FDA Adverse Event Reporting System, GE GE Healthcare MQIC (Medical Quality Improvement Consortium) database, GIB upper gastrointestinal bleeding, NYP/CUMC New York Presbyterian Hospital at Columbia University Medical Center