Figure 3.

Crystal Structure of NU6300 Bound to CDK2/Cyclin A

(A) CDK2 and cyclin A are rendered in ribbon representation and colored mint blue and lemon, respectively. NU6300 is shown in ball-and-stick representation, with carbon atoms in yellow.

(B) Schematic representation of the hydrogen bonds made between backbone atoms of CDK2 residues Glu81, Leu83, and Asp86, located in the hinge region, and NU6300 to illustrate the binding mode. Hydrogen bonds are drawn as arrows.

(C) Electron density map at the CDK2 active site. The 2F₀-F_c map is contoured at 0.2 e⁻ A³. CDK2 and NU6300 carbon atoms are colored green and yellow, respectively.

See also Figure S2 and Table S2.