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. 2015 Aug 10;49(5):373–381. doi: 10.4132/jptm.2015.07.09

Table 3.

Clinicopathologic characteristics and immunohistochemical stain results of 190 HCCs

SALL4
p-value K19a
p-value EpCAMa
p-value
Negative Positive Negative Positive Negative Positive
Frequency 151 (79.5) 39 (20.5) 159 (84.1) 30 (15.9) 97 (51.3) 92 (48.7)
Age (yr) .858 .694 .020
 < 60 81 (53.6) 20 (51.3) 83 (52.2) 17 (56.7) 43 (44.3) 57 (62.0)
 ≥ 60 70 (46.4) 19 (48.7) 76 (47.8) 13 (43.3) 54 (55.7) 35 (38.0)
Sex 1.000 .808 .113
 Male 32 (21.2) 8 (20.5) 33 (20.8) 7 (23.3) 16 (16.5) 24 (26.1)
 Female 119 (78.8) 31 (79.5) 126 (79.2) 23 (76.7) 81 (83.5) 68 (73.9)
Etiology .319 .829 .010
 Hepatitis B virus–related 40 (26.5) 14 (35.9) 45 (29.3) 9 (30.0) 36 (37.1) 18 (19.6)
 Non-hepatitis B virus–related 111 (73.5) 25 (64.1) 114 (71.7) 8 (70.0) 61 (62.9) 74 (80.3)
Serum α-fetoprotein (IU/mL) (n = 132) 1.000 .032 .023
 < 1,000 76 (76) 25 (78.1) 86 (80.4) 14 (58.3) 54 (85.7) 46 (79.3)
 ≥ 1,000 24 (24) 7 (21.9) 21 (19.6) 10 (41.7) 9 (14.3) 22 (20.7)
Multiplicity .825 .328 .372
 Absent 120 (79.5) 32 (82.1) 129 (81.1) 22 (73.3) 80 (82.5) 71 (77.2)
 Present 31 (20.5) 7 (17.9) 30 (18.9) 8 (26.7) 17 (17.5) 21 (22.8)
Tumor size (cm)b .432 .076 .873
 < 5 105 (69.5) 30 (76.9) 118 (74.2) 17 (56.7) 70 (72.2) 65 (70.7)
 ≥ 5 16 (30.5) 9 (23.1) 41 (25.8) 13 (43.3) 27 (27.8) 27 (29.3)
Pathologic T stage 1.000 .011 .266
 pT1/pT2 122 (80.8) 32 (82.1) 134 (84.3) 19 (63.3) 82 (84.5) 71 (77.2)
 pT3a/pT3b/pT4 29 (19.2) 7 (17.9) 25 (15.7) 11 (36.7) 15 (15.5) 21 (22.8)
Edmondson-Steiner grade .410 .648 .019
 I/II 36 (23.8) 12 (30.8) 42 (26.4) 6 (20.0) 32 (33) 16 (17.4)
 III/IV 115 (76.2) 27 (69.2) 117 (73.6) 24 (80.0) 65 (67) 76 (82.6)
Microvascular invasion .581 .685 .011
 Absent 94 (62.3) 22 (56.4) 98 (61.6) 17 (56.7) 68 (70.1) 47 (51.1)
 Present 57 (37.7) 17 (43.6) 61 (38.4) 13 (43.3) 29 (29.9) 45 (48.9)
Major vessel invasionc .781 .010 .366
 Absent 134 (88.7) 34 (87.2) 145 (91.2) 22 (73.3) 88 (90.7) 79 (85.9)
 Present 17 (11.3) 5 (12.8) 14 (8.8) 8 (26.7) 9 (9.3) 13 (14.1)

Values are presented as number (%).

HCC, hepatocellular carcinomas; SALL4, Sal-like protein 4; EpCAM, epithelial cellular adhesion molecule.

a

n = 189 (tissue core loss in 1 case);

b

Size of largest tumor in case of multiple tumors;

c

Main or first order branches of portal vein and/or one or more of right, middle or left hepatic veins.