Figure 5. SC depletion leads to declines in force generation of skeletal muscles after neuromuscular disruption.
(A) Average time to peak tension (TTP) during 150 Hz stimulation in EDL muscles. *p < 0.05 compared to Ctrl and P7DTA sham. ANOVA/Bonferroni multiple comparisons test, N = 4–6. (B) Absolute and (C) Specific force frequency curves for Ctrl and P7DTA EDL muscles 6 weeks after SNT surgery. *p < 0.05 compared to Ctrl SNT at indicated frequency, t-tests, N = 4–6 mice.
Figure 5—figure supplement 1. Reduced contractile force and slowed force development in EDL muscles following SNT.
(A). Representative traces for specific force from in vitro muscle contraction measurements in EDL muscles stimulated at 150hz for 500ms. (B). Same traces as (A) but normalized to the corresponding peak and expanded for the first 200ms of stimulation to show the delayed force development in muscles following SNT.