Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Oct;25(10):1442–1455. doi: 10.1101/gr.190124.115

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 Hilton and Gersbach; Published by Cold Spring Harbor Laboratory Press

This article, published in Genome Research, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Figure 3. — Outlook for genome engineering technologies. (A) Genome editing technologies can be used to incorporate genome-wide association study (GWAS)-identified single nucleotide polymorphisms (SNPs) into models of complex diseases and to ascertain casual disease variants. (B) Human cells can be programmed using genome engineering to produce the next generation of advanced cell therapies. (C) Techniques designed to assess potential off-target activity of programmable nucleases and transcriptional/epigenetic modifiers will facilitate technology improvements. (D) Increased control of genome engineering tools can be achieved with chemical and optogenetic regulation to develop highly articulated systems with increased specificity and dynamic properties.