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. 2015 Oct;25(10):1558–1569. doi: 10.1101/gr.194118.115

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© 2015 Org et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genome Research, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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Figure 2. — Cross-fostering influences dietary responsiveness. (A) Body fat increase in SWR and A×B19 strains during 8 wk of the HF/HS diet. (B) Principal Coordinate Analysis (PCoA) of unweighted UniFrac distances for fecal samples after cross-fostering newborn SWR and A×B19 pups between parents (blue = A×B19 mothers, red = SWR mothers, and green = cross-fostered SWR pups), P < 0.05 for unweighted UniFrac using Student's t-test with 1000 Monte Carlo simulations. (C) Body fat changes after cross-fostering SWR pups with A×B19 mother (CF-SWR) compared to SWR and A×B19 controls. (D) Total body fat percentage after 8 wk of HF/HS feeding. (E) Plasma triglycerides (TG) levels. (F) PCoA of unweighted UniFrac distances for cecum samples after 8 wk of the HF/HS diet (blue = A×B19, red = SWR, green = cross-fostered SWR). Significant differences: (*) P < 0.05, (****) P < 0.0001, according to unpaired two-tailed Student's t-test. See also Supplemental Figure 2.