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The C. elegans rec-1 mutations map to y18h1a.7. (A) The s180 allele was identified by a whole-genome sequencing experiment described previously (Rose et al. 2010). Four alleles of rec-1 were generated by CRISPR–Cas9 (Friedland et al. 2013) using the same target guide RNA sequence and the protospacer-adjacent motif (PAM). (B) The mutant alleles of rec-1 encode truncated versions of REC-1. Amino acid differences from the wild-type translation are colored in red.
