Figure 7.
Development of the sympathetic nervous system is phenotypically normal in Gfrα1TM/TM mice. Whole-mount tyrosine hydroxylase immunohistochemistry of P0 mice demonstrates normal positioning of the SCG (left) and the normal positioning and caudal axonal projections to structures of the STG (middle). The sympathetic chain ganglia (right) in Gfrα1+/+ and Gfrα1TM/TM mice are also phenotypically normal and display similar axonal projections. Identical phenotypes were observed from three to five individual mice of each genotype from two to three independent litters.