Figure 2.

Effect of vortioxetine and paroxetine on rapid eye movement (REM), non-rapid eye movement (NREM), wake (quiet wake and active wake), and REM/NREM ratio during 12-hour light phase (06:00–18:00). Data shown reflect mean±standard error of the mean (SEM) of the sum of time spent in each stage for each 30-minute epoch after drug administration for day 1 or the whole light phase for all other days. Each treatment group was compared to its respective vehicle control for each day separately (*p<0.05; **p<0.01; ***p<0.005).