Figure 3.

Effect of vortioxetine and paroxetine on rapid eye movement (REM), non-rapid eye movement (NREM), wake (quiet wake and active wake), and REM/NREM ratio during 12-hour dark phase (18:00–06:00). Data shown reflects mean± standard error of the mean (SEM) of the sum of time spent in each stage for each 30-minute epoch after drug administration for day 1 or the whole light phase for all other days. Each treatment group was compared to its respective vehicle control for each day separately (*p<0.05; **p<0.01; ***p<0.005).