Figure 6.

Rapid eye movement (REM) onset latency following acute administration of vortioxetine alone and in combination with SR57227A shows that the 5-HT₃ agonist increased REM onset latency (*p<0.05, unpaired t-test). SR57227A alone induced a significant delay in REM onset compared to vehicle (p<0.001). Vortioxetine alone was not different than vehicle (p=0.228), however SR57227A in combination with vortioxetine significantly delayed (increased) REM onset compared to vortioxetine alone (p=0.003, unpaired t-test).