Skip to main content
. Author manuscript; available in PMC: 2015 Sep 23.
Published in final edited form as: Mol Cell. 2015 Sep 3;59(6):970–983. doi: 10.1016/j.molcel.2015.07.028

Figure 1. Structure of the BRCC36–KIAA0157 complex.

Figure 1

A) Cleavage activity of CfBRCC36 and CfBRCC36-containing complexes towards an internally quenched K63-diUb fluorogenic substrate. Results ± SEM are the average of three independent experiments carried out in duplicate.

B) Structure of the CfBRCC36–KIAA0157ΔC complex. Contents of the asymmetric unit revealed two CfBRCC36–KIAA0157ΔC complexes forming a dimer of heterodimers (super dimer).

C) Ribbon representation of the CfBRCC36–KIAA0157ΔC heterodimer. Zoom in panels show a detailed view of interacting residues. Disordered regions are shown as dashed lines. Interacting residues analyzed by mutation are labeled in red. See also Figures S1-S4 and S6.