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. Author manuscript; available in PMC: 2016 Jan 2.
Published in final edited form as: Nat Commun. 2015 Jul 2;6:7629. doi: 10.1038/ncomms8629

Figure 9. Proposed mechanism by which L-cell FXR decreases GLP-1 production and secretion.

Figure 9

Glucose induces proglucagon gene expression in L-cells via the glycolysis pathway and ChREBP, and subsequently promotes GLP-1 production. Moreover, glycolysis increases intracellular ATP concentrations and induces GLP-1 secretion. FXR activation, by inhibiting glucose metabolism, decreases both GLP-1 production and secretion. Colesevelam, by inhibiting FXR transcriptional activity in L-cells, promotes GLP-1 production and secretion.