Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Sep 22;10:118. doi: 10.1186/s13023-015-0343-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Albiñana et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 2 — Propranolol decreases the expression of HIF target genes in hemangioblastoma cells. a The transcription levels of HIF target genes, VEGF, EPO and SOX2, were compared with the endogenous control of 18S ribosomal RNA. Propranolol treatment led to a dose-dependent decrease in mRNA expression as a consequence of the reduced expression of HIF targets. Differences were statistically significant according to the Student’s t-test. *P < 0.05; **P < 0.01; ***P < 0.005. b VEGF soluble levels were measured by ELISA assay in supernatants of hemangioblastoma cultures treated with propranolol. Soluble VEGF levels were decreased in propranolol-treated cells compared with untreated ones