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. 2015 Sep 23;3:10. doi: 10.1186/s40170-015-0135-3

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© Cluntun et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Quantitative proteomics identifies specific dose-dependent changes in histone acetylation. a Schematic of SILAC experiment workflow. b Heatmap of all detected histone acetylated residues in response to 2DG treatment. Values are row-normalized with red denoting high and blue denoting low. c Correlation coefficients of acetylated histones in relation to CoA and ac-CoA levels. d Quantification of the difference in sensitivity of ac-Histone residues to 2DG treatment