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. 2015 Mar 4;68(8):485–490. doi: 10.1038/ja.2015.18

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Copyright © 2015 Japan Antibiotics Research Association

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Linezolid (LIN), vancomycin (VAN) and daptomycin (DAP) differentially modulate the expression of Toll-like receptors (TLRs) in monocytes. THP-1 monocytes were incubated with LIN, VAN or DAP in the presence or absence of lipopolysaccharide (LPS) for 24 h. Quantitative real-time-PCR (qRT-PCR) analysis was performed to determine the expression levels of genes encoding TLR1 (a), TLR2 (b), TLR4 (c), TLR6 (d), TLR7 (e) and TLR9 (f) after normalization to GAPDH. Each bar represents the fold change in mRNA expression comparing unstimulated control with antibiotic-incubated cells or LPS-stimulated control with LPS plus antibiotic-stimulated cells, respectively. Data are expressed as mean±s.e.m. of six independent experiments; *P<0.05 vs respective LPS-free control; ⁺P<0.05 vs respective LPS control.