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. 2015 Feb 16;12(5):558–565. doi: 10.1038/cmi.2015.10

Figure 2.

Figure 2

Enzymes responsible for post-translational modification of FOXP3 are potential therapeutic targets for inflammation. Inhibitors of FOXP3 positive regulators, including P300/TIP60, USP7 and PPase, could be used to activate immune system through downregulating the immunosuppressive activity of Treg cells; inhibitors of FOXP3 negative regulators, including SIRT1/HDAC9, STUB1 and PIM1, could be used to put a brake on immune responses through upregulating the immunosuppressive function of Treg cells. Treg, regulatory T.